报告人：Xingde Li, PhD, Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA

时  间：2024年7月21日（周日）10:00

地  点：深圳大学粤海校区致原楼1214

Abstract: Imaging with low-coherence light offers excellent intrinsic resolution and has significant potential for clinical translation. One challenge of high-resolution optical imaging is the limited imaging depth. Fiber-optic based endoscopes and endomicroscopes are essential for the clinical translation of high-resolution, low-coherence optical imaging in the assessment of internal organs. This presentation will highlight our recent progress in developing ultrahigh-resolution OCT endoscopy and multiphoton endomicroscopy technologies, which enable label-free imaging of tissue microanatomy in vivo, in situ, and in real time. These technologies achieve resolutions from morphological to cellular and subcellular levels, comparable to standard histopathology, without the need for tissue removal, staining, or processing. The presentation will cover the underlying physics principles, engineering challenges, and solutions. Representative applications of these optical technologies will be discussed, including cancer detection, small airway pathophysiology imaging, preterm birth risk assessment, and intra-operative guidance for neurosurgery. Additionally, potential applications in basic research, such as functional neuroimaging on freely walking animals, will be explored.

SHORT BIOSKETCH

Xingde Li earned his PhD in Physics from the University of PENN in 1998. Following 3 years of postdoctoral training at MIT, he began his academic career as Assistant Professor at the University of Washington. In 2009, he joined the BME Department at Johns Hopkins as Associate Professor and later became a Full Professor in 2011. His research is centered around on biophotonics imaging technologies and their applications in translational and basic research. He has published about 150 journal papers, with a total citation around 23,000 and an H-index of 65 (Google Scholar). Beyond research endeavors, he has actively participated in various committees for different societies, chaired numerous international conferences, and served on many proposal review panels. He has also taken on editorial roles as a topical editor, associate editor for several journals and the lead founding EiC for a Science Partner Journal – BMEF. He has been elected Fellow of OPTICA, SPIE, and AIMBE