时 间：2024年11月12日（周二）10:20
地 点：深圳大学粤海校区光电子研究所多功能厅301
报告人：Valery V. Tuchin
Email: tuchinvv@mail.ru
Institute of Physics and Science Medical Center, Saratov State University
Institute of Precision Mechanics and Control, FRS “Saratov Scientific Centre of the Russian Academy of Sciences”
Laboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, Russia
Tissue optical clearing (TOC) is based on temporary and reversible suppression of light scattering in tissues and organs using biocompatible immersion optical clearing agents (OCAs) [1,2]. Delivery of the appropriate OCA to living tissue ensures its temporal transparency over a wide spectral range from deep UV to THz, thereby providing higher image depth and contrast for various optical methods and better precision of laser treatments and their optical monitoring.
The presentation summarizes the latest advances in the development of the TOC method for solving problems of intravital optical spectroscopy and imaging. The combination of optical techniques with X-ray CT and MRI is possible through the use of commercial contrast agents. The optical clearing method provides additional markers for monitoring diabetes mellitus complications and cancer detection, as well as important data for optimal cryopreservation of organs.
References
1. L. Oliveira and V. V. Tuchin, The Optical Clearing Method: A New Tool for Clinical Practice and Biomedical Engineering, Springer Nature Switzerland AG, Basel, 2019 – 177 p.
2. V. V. Tuchin, D. Zhu, E. A. Genina (Eds.), Handbook of Tissue Optical Clearing: New Prospects in Optical Imaging, CRC Press, Boca Raton, FL, 2022 – 688 p.
3. V.V. Tuchin, E.A. Genina, E.S. Tuchina, A.V. Svetlakova, Y.I. Svenskaya, Optical clearing of tissues: issues of antimicrobial phototherapy and drug delivery, Advanced Drug Delivery Reviews 180 (1), 114037 (2022).
4. I.S. Martins, H.F. Silva, E.N. Lazareva, N.V. Chernomyrdin, K.I. Zaytsev, L.M. Oliveira, and V.V. Tuchin, Measurement of tissue optical properties in a wide spectral range: a review [Invited], Biomedical Optics Express, 14 (1), 249-298 (2023).
5. A.S. Shanshool, S. Ziaee, M.A. Ansari, V.V. Tuchin, Advances in the transport of laser radiation to the brain with optical clearing: From simulation to reality (Invited Review), Progress in Quantum Electronics 94, 100506 (2024).
6. D. Zhu, V.V. Tuchin, Tissue optical clearing imaging from ex vivo toward in vivo, BME Front. 5, 0058 (2024).
Valery V. Tuchin is a Corresponding Member of the Russian Academy of Sciences, Head of the Department of Optics and Biophotonics and Director of the Science Medical Center of Saratov State University. He is also works with several other research centers. He is a laureate of many national and international awards in biophotonics and biomedical optics, has published more than 40 books and 1000 articles that have been cited more than 42,000 times.
